Human ADRA2B-Strep full length protein-synthetic nanodisc

Name: Human ADRA2B-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120187

Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

SKU: FLP120187 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data Dima FAQ

Tag	C-Flag&Strep Tag
Target	ADRA2B
Synonyms	ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR; ALPHA2BAR; FAME2
Description	Human ADRA2B-Strep full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P18089
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction
Molecular Weight	The human full length ADRA2B-Strep protein has a MW of 50.0 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Usage	Research use only
Conjugate	Unconjugated

图片 Dima FAQ

Figure 1. Elisa plates were pre-coated with C-Flag&Strep Tag ADRA2B-Strep-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with ADRA2B-Strep-nanodisc is 6.225ng/ml.

Figure 2. Human ADRA2B-Strep-Nanodisc, C-Flag&Strep Tag on SDS-PAGE

Human ADRA2B-Strep full length protein-synthetic nanodisc

Product Data Dima FAQ

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