| Target | |
|---|---|
| Synonyms | PD1; PDCD1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; AIMTBS |
| Description | Recombinant human PD-1 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q15116 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | PD-1(Leu25-Thr145) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 39.7 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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