| Target | |
|---|---|
| Synonyms | AITR;GITR;TNFRSF18;CD357 |
| Description | Recombinant human GITR protein with C-terminal human Fc and 6×His tag |
| Delivery | In Stock |
| Uniprot ID | Q9Y5U5 |
| Expression Host | HEK293 |
| Tag | C-Human Fc and 6×His Tag |
| Molecular Characterization | GITR(Gln26-Pro162) hFc(Glu99-Ala330) 6×His |
| Molecular Weight | The protein has a predicted molecular mass of 51-52 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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