Human CCR2 full length protein-synthetic nanodisc

Name: Human CCR2 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100028
Price: 8000.00 USD
Availability: InStock

Price: 10 μg ￥6300.00 ;50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100028 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data

Tag	C-Flag Taq
Target	CCR2
Synonyms	CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
Description	Human CCR2 full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P41597
Expression Host	HEK293
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction
Molecular Weight	The human full length CCR2 protein has a MW of 41.9 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Usage	Research use only

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elisa-FLP100028 CCR2 Fig.1 Elisa 1
Figure1. Elisa plates were pre-coated with Flag Tag CCR2-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with CCR2-Nanodisc is 7.62ng/ml.
page-FLP100028 CCR2 Fig.2 SDS PAGE 1
Figure2. Human CCR2-Nanodisc, Flag Tag on SDS-PAGE
page-FLP100028 CCR2 Fig.3 SDS PAGE 2
Figure3. WB analysis of Human CCR2-Nanodisc with anti-CCR2 monoclonal antibody (BME100087), followed by Goat Anti-Human IgG HRP at 1/5000 dilution

Human CCR2 full length protein-synthetic nanodisc

Product Data

图片

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