| Target | |
|---|---|
| Synonyms | VSIG9; VSTM3; WUCAM |
| Description | Recombinant Cynomolgus TIGIT protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | A0A7N9I9V4 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | TIGIT(Lys27-Pro209) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 46.6 kDa after removal of the signal peptide. The apparent molecular mass of cTIGIT-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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