| Target | |
|---|---|
| Synonyms | EPHA2, EphA2, ECK, EPH Receptor A2, Ephrin Type-A Receptor 2, Epithelial Cell Kinase, Tyrosine-Protein Kinase Receptor ECK |
| Description | Recombinant Cynomolgus EPHA2 protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | Q1KL86 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | EPHA2(Ala24-Val537)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 58.0 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | EPHA2, also known as EphA2 or ECK, is a type I transmembrane receptor tyrosine kinase belonging to the Eph receptor family. The extracellular region contains an ephrin-binding domain, a cysteine-rich region, and two fibronectin type III domains, while the intracellular region contains a protein tyrosine kinase domain and a sterile alpha motif. EPHA2 binds membrane-associated ephrin-A ligands, particularly ephrin-A1, and mediates contact-dependent signaling between adjacent cells. EPHA2 signaling regulates cell adhesion, migration, proliferation, differentiation, angiogenesis, and tissue development. Dysregulated expression or activation of EPHA2 has been observed in multiple cancers and is associated with tumor growth, invasion, metastasis, and treatment resistance. Therefore, EPHA2 is an important target for cancer biology, antibody development, targeted drug delivery, and immuno-oncology research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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