| Target | |
|---|---|
| Synonyms | CD8A, CD8, CD8 Alpha, CD8α, CD8alpha, Leu2, p32, T-Cell Surface Glycoprotein CD8 Alpha Chain, CD8 Subunit Alpha |
| Description | Recombinant Cynomolgus CD8A Acidic tail Protein with C-terminal 6×His tag |
| Delivery | In STOCK |
| Uniprot ID | XP_065382910.1 |
| Expression Host | HEK293 |
| Tag | C-6×His tag |
| Molecular Characterization | CD8A(Ser22-Ile185)+Acidic tail+6×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 20.0 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | CD8A, also known as CD8 alpha, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is primarily expressed on cytotoxic T lymphocytes and subsets of natural killer cells and dendritic cells. CD8A can form either an alpha-alpha homodimer or an alpha-beta heterodimer with CD8B. The CD8 coreceptor binds to major histocompatibility complex class I molecules and cooperates with the T-cell receptor to promote antigen recognition and T-cell activation. Its cytoplasmic region associates with the Src-family kinase LCK, facilitating intracellular signaling following T-cell receptor engagement. CD8A is widely used as a marker of cytotoxic T cells and is an important target in immunology, infectious disease, cancer immunology, and cell-therapy research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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