| Target | |
|---|---|
| Synonyms | H1R, Histamine H1 receptor, Histamine receptor 1 |
| Description | Recombinant human HRH1 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P35367 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | HRH1(Met1-Leu27) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 29.1 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | HRH1 (Histamine receptor H1) is a G-protein coupled receptor (GPCR) that primarily couples to Gq/11 proteins, activating phospholipase C (PLC), increasing IP₃/DAG levels and intracellular Ca²⁺ mobilization. HRH1 is expressed in smooth muscle, endothelial cells, brain, and immune cells, mediating allergic responses, vasodilation, bronchoconstriction, and neurotransmission. Dysregulation of HRH1 signaling is associated with allergies, asthma, inflammation, and CNS disorders, making it a therapeutic target for antihistamines and allergy treatments. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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