| Target | |
|---|---|
| Synonyms | FFAR3, GPR41, FFA3, Free fatty acid receptor 3, G-protein coupled receptor 41 |
| Description | Recombinant human FFAR3 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | O14843 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | FFAR3(Met1-Trp15) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 27.9 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | FFAR3 (Free fatty acid receptor 3 / GPR41) is a G-protein coupled receptor (GPCR) that binds short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It primarily couples to Gi/o proteins, inhibiting adenylyl cyclase and modulating cAMP levels. FFAR3 is expressed in adipose tissue, gut, and sympathetic neurons, where it regulates energy metabolism, insulin secretion, gut hormone release, and sympathetic nervous system activity. Dysregulation of FFAR3 signaling is implicated in metabolic disorders, obesity, and diabetes, making it a potential therapeutic target in metabolic and cardiovascular diseases. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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