| Target | |
|---|---|
| Synonyms | CRLR; CGRPR; LMPHM8 and RAMP1 |
| Description | Recombinant human CGRPR protein with C-terminal human Fc tag and human RAMP1 protein with C-terminal mouse Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q16602 and O60894 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag and C-mouse Fc tag |
| Molecular Characterization | CGRPR(Glu23-Asn140) hFc(Glu99-Ala330) and RAMP1(Cys27-Ser117) mFc(Pro99-Lys330) |
| Molecular Weight | The protein has a predicted molecular mass of 39.9 and 36.7 kDa after removal of the signal peptide. The apparent molecular mass of CGRPR-hFc and RAMP1-mFc is approximately 35-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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