| Target | |
|---|---|
| Synonyms | LILRB4, LILRB4A, Lilrb4a, Lilrb4, CD85K, Gp49b, Gp49B, GP49B1, HM18, ILT3, ILT-3, Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4A, Leukocyte Immunoglobulin-Like Receptor B4A |
| Description | Recombinant mouse LILRB4 protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | Q64281 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | Mouse LILRB4(Gly24-Lys238)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 25.4 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | LILRB4A, also known as Gp49b, is a type I transmembrane inhibitory receptor belonging to the leukocyte immunoglobulin-like receptor family. It contains extracellular immunoglobulin-like domains, a single transmembrane region, and cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. LILRB4A is expressed on several myeloid immune-cell populations, including monocytes, macrophages, dendritic cells, and mast cells. Following receptor engagement, its intracellular inhibitory motifs recruit phosphatases and suppress cellular activation, inflammatory signaling, cytokine production, and degranulation. LILRB4A contributes to immune homeostasis and the negative regulation of innate immune responses, making it an important target for inflammation, autoimmune disease, myeloid-cell biology, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
服务热线
400-006-0995
18062749453
