| Target | |
|---|---|
| Synonyms | A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5 |
| Description | Recombinant human LRP1(3332-3779) Protein with C-terminal human Fc tag |
| Delivery | In STOCK |
| Uniprot ID | Q07954 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | LPR1(Ser3332-Asp3779)+hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 76.3 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | LRP1 (Low-density lipoprotein receptor-related protein 1), also known as CD91, is a large multifunctional endocytic and signaling receptor belonging to the low-density lipoprotein receptor family. It is widely expressed in various tissues and cell types and participates in the binding, internalization, and clearance of numerous ligands, including lipoproteins, proteases, protease–inhibitor complexes, extracellular matrix proteins, and growth factors. Through its extracellular ligand-binding domains and intracellular signaling motifs, LRP1 regulates lipid metabolism, protein clearance, cell migration, inflammation, vascular homeostasis, and blood–brain barrier function. Dysregulation of LRP1 has been associated with cardiovascular diseases, neurodegenerative disorders, fibrosis, and cancer. Recombinant LRP1 protein is suitable for receptor–ligand interaction studies, antibody screening, binding assays, drug-delivery research, and investigations of LRP1-mediated endocytosis and signaling pathways. |
| Usage | Research use only |
| Conjugate | Unconjugated |
服务热线
400-006-0995
18062749453
