| Target | |
|---|---|
| Synonyms | KIA; MIB-; MIB-1; PPP1R105; MKI67 |
| Description | Recombinant human KI67(1206-1238) Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P46013 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | KI67(Gly1206-Glu1238) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 29.8 kDa after removal of the signal peptide. The apparent molecular mass of KI67(1206-1238)-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis. [provided by Alliance of Genome Resources, Apr 2022] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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