| Target | |
|---|---|
| Synonyms | IL-15,CD215 |
| Description | Recombinant human IL15(N120D) protein with C-terminal human Fc tag and human IL15RA protein |
| Delivery | In Stock |
| Uniprot ID | Q13261 and P40933 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag and tag Free |
| Molecular Characterization | IL15(Asn49-Ser162,N120D) hFc(Glu99-Ala330) IL15RA(Ile31-Arg95) |
| Molecular Weight | The protein has a predicted molecular mass of 38.9kDa and 7.3kDa kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Interleukin-15 is a member of the four α helix bundle family of cytokines. It plays a multifaceted role in the development and control of the immune system. The IL-15R consists of three polypeptides, the type-specific IL-15Rα, the IL-2/IL-15Rβ, and the common γ-chain (γC), which is shared by multiple cytokine receptors. IL-15 could enhance the effect of chemotherapeutic agents and ACT on transplanted tumors, but had little or no effect when administered alone. The result of research shows that the biological activity of IL-15 could be increased ∼50-fold by administering preformed complexes of IL-15 and its soluble receptor, IL-15Rα. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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