| Target | |
|---|---|
| Synonyms | OX2R, Orexin receptor 2, Hypocretin receptor 2 |
| Description | Recombinant human HCRTR2 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | O43614 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | HCRTR2(Met1-Lys51) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 32.3 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | HCRTR2 (Orexin receptor 2 / Hypocretin receptor 2) is a G-protein coupled receptor (GPCR) expressed in the central nervous system, particularly in hypothalamic neurons. It couples to Gq and Gi/o proteins, activating PLC/Ca²⁺ signaling and modulating adenylyl cyclase and MAPK pathways. HCRTR2 regulates wakefulness, sleep-wake cycles, appetite, and energy homeostasis. Dysregulation is associated with narcolepsy, sleep disorders, and metabolic dysfunctions, making it a therapeutic target for sleep and metabolic disorders. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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