| Target | |
|---|---|
| Synonyms | GPR17A, GPR17B, P2Y12-like receptor, P2Y-like receptor |
| Description | Recombinant human GPR17 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q13304 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | GPR17(Met1-Leu61) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 32.8 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | GPR17 (G protein-coupled receptor 17) is a G-protein coupled receptor (GPCR) expressed in oligodendrocyte precursor cells, brain, and spinal cord. It couples to Gi/o and Gq proteins, modulating cAMP, intracellular calcium, and MAPK signaling. GPR17 plays a key role in oligodendrocyte differentiation, myelination, and response to CNS injury. Dysregulation is associated with neurodegenerative disorders, demyelinating diseases, and CNS repair mechanisms, making it a potential therapeutic target in neurological and demyelinating conditions. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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