| Target | |
|---|---|
| Synonyms | D2R; D2DR |
| Description | Recombinant human DRD2 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P14416 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | DRD2(Met1-Asn35) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 30.3 kDa after removal of the signal peptide. The apparent molecular mass of DRD2-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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