| Target | |
|---|---|
| Synonyms | CT‑R; CTR; CRT; CTR1; C1A; Calcitonin receptor |
| Description | Recombinant human CALCR Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P30988 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | CALCR(Ala25-Tyr146) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 40.6 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | CALCR encodes the calcitonin receptor, a G-protein coupled receptor (GPCR) that binds calcitonin, a hormone involved in calcium and bone homeostasis. CALCR primarily couples to Gs proteins, stimulating adenylyl cyclase and increasing intracellular cAMP, and can also couple to Gq/11 proteins to trigger phospholipase C signaling. It is expressed in osteoclasts, kidney, brain, and thyroid C-cells, where it regulates bone resorption, calcium metabolism, and neuroendocrine functions. CALCR is a therapeutic target for osteoporosis, Paget’s disease, and other bone disorders, and is also studied in pain modulation and metabolic regulation. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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