| Target | |
|---|---|
| Synonyms | AZ3B; C3AR; C3R1; HNFAG09; C3a anaphylatoxin chemotactic receptor |
| Description | Recombinant human C3AR1 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q16581 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | C3AR1(Met1-Val23) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 28.7 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | C3AR1 encodes the C3a receptor (C3aR1), a G-protein coupled receptor (GPCR) that binds the complement component C3a, a key anaphylatoxin in the immune system. C3AR1 couples primarily to Gi proteins, leading to inhibition of adenylyl cyclase, Ca²⁺ mobilization, and activation of MAPK and NF-κB signaling. It is expressed on immune cells including neutrophils, monocytes, macrophages, and mast cells, where it mediates chemotaxis, degranulation, cytokine release, and inflammatory responses. C3AR1 plays a critical role in innate immunity, inflammation, and host defense, and dysregulation is implicated in allergic diseases, sepsis, autoimmune disorders, and cancer. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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