| Target | |
|---|---|
| Synonyms | HTX4; ACTRIIB; ActR-IIB |
| Description | Recombinant human ACVR2B Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q13705 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | ACVR2B(Ser19-Thr137) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 39.8 kDa after removal of the signal peptide. The apparent molecular mass of ACVR2B-hFc is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
Human ACVR2B Protein, hFc Tag
Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00
Product Data
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Figure 1. Human ACVR2B Protein, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human ACVR2B Protein, hFc Tag (PME101551) can bind Anti-ACVR2B(bimagrumab biosimilar) mAb (BME100228) in a linear range of 0.64–80 ng/mL.