| Target | |
|---|---|
| Synonyms | SFTA5; SFTPJ |
| Description | Recombinant Cynomolgus CLDN18.2 protein with N-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | A0A2K5VV62 |
| Expression Host | HEK293 |
| Tag | N-Human Fc tag |
| Molecular Characterization | hFc(Glu99-Ala330) CLDN18.2(Asp28-Gln77) |
| Molecular Weight | The protein has a predicted molecular mass of 31.9 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] |
| Usage | Research use only |
Cynomolgus CLDN18.2 Protein, hFc Tag
Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
Product Data
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Figure 1. Cynomolgus CLDN18.2 Protein, hFc Tag on SDS-PAGE under reducing condition.