| Target | |
|---|---|
| Synonyms | CD4, T4, Leu-3, OKT4, OKT4D, T-Cell Surface Glycoprotein CD4, CD4 Molecule, T-Cell Surface Antigen T4, T-Helper Cell Marker |
| Description | Recombinant Cynomolgus CD4 protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | P79185 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | CD4(Lys26-Pro396)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 42.4 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | CD4 is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is primarily expressed on helper T lymphocytes and is also found on subsets of monocytes, macrophages, dendritic cells, and other immune cells. CD4 functions as a coreceptor for the T-cell receptor by binding to major histocompatibility complex class II molecules on antigen-presenting cells. The cytoplasmic region of CD4 associates with the Src-family kinase LCK and enhances signaling required for T-cell activation, differentiation, and cytokine production. CD4 plays a central role in the development and function of helper T-cell subsets and the coordination of adaptive immune responses. It is widely used as an immune-cell marker and as a target in immunology, infectious disease, autoimmune disease, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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