| Target | |
|---|---|
| Synonyms | TNFRSF4, OX40, CD134, OX40L receptor, ACT35, TXGP1L |
| Description | Recombinant human OX40 protein with C-terminal human Fc and 6×His Avi tag |
| Delivery | In STOCK |
| Uniprot ID | P43489 |
| Expression Host | HEK293 |
| Tag | C-Human Fc and 6×His Avi tag |
| Molecular Characterization | OX40(Leu29-Ala214)+hFc(Glu99-Ala330)+6×His+Avi tag |
| Molecular Weight | The protein has a predicted molecular mass of 49.0 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
| Usage | Research use only |
| Conjugate | Biotinylated |
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