| Target | |
|---|---|
| Synonyms | IGFBP2, IGFBP-2, BP2, IBP2, IGF-Binding Protein 2, Insulin-Like Growth Factor-Binding Protein 2, Insulin-Like Growth Factor Binding Protein 2 |
| Description | Recombinant human IGFBP2 protein with C-terminal human Fc tag |
| Delivery | In STOCK |
| Uniprot ID | P18065 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | IGFBP2(Ala36-Gln325)+hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 57.6 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | IGFBP2, also known as insulin-like growth factor-binding protein 2, is a secreted glycoprotein belonging to the insulin-like growth factor-binding protein family. It binds insulin-like growth factors IGF1 and IGF2 with high affinity and regulates their stability, distribution, availability, and interaction with IGF receptors. Through these activities, IGFBP2 modulates IGF-dependent cellular processes, including cell proliferation, differentiation, survival, migration, and apoptosis. IGFBP2 can also exert IGF-independent effects through interactions with cell-surface molecules, extracellular matrix components, and intracellular partners. It is expressed in multiple tissues and biological fluids and plays important roles in development, metabolism, tissue homeostasis, and tumor biology. Aberrant IGFBP2 expression has been reported in several cancers, making it a potential biomarker and therapeutic research target. |
| Usage | Research use only |
| Conjugate | Unconjugated |
服务热线
400-006-0995
18062749453
