| Target | |
|---|---|
| Synonyms | IGIF, IL-18, IL-1g, IL1F4 |
| Description | Recombinant Cynomolgus IL18 protein with C-terminal human Fc tag |
| Delivery | In STOCK |
| Uniprot ID | A0A2K5TJ84 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | Cynomolgus IL18(Tyr37-Asp193) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 44.4 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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