| Target | |
|---|---|
| Synonyms | CD2, T11, SRBC, LFA-2, Leu-5, E-Rosette Receptor, Sheep Red Blood Cell Receptor, T-Cell Surface Antigen CD2, T-Cell Surface Antigen T11, Lymphocyte Function-Associated Antigen 2 |
| Description | Recombinant Cynomolgus CD2 protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | Q6SZ61 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | CD2(Lys25-Asp209)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 22.8 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | CD2 is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is predominantly expressed on T lymphocytes, natural killer cells, and thymocytes. The extracellular region of CD2 interacts with CD58, also known as LFA-3, on antigen-presenting cells and other cell types. This interaction promotes cell-cell adhesion, stabilizes the immunological synapse, and enhances immune recognition. In addition to its adhesive function, CD2 acts as a costimulatory receptor that regulates T-cell and natural killer cell activation, proliferation, cytokine production, and cytotoxicity. CD2 is widely used as a marker of T-cell and natural killer cell lineages and is also expressed in many T-cell lymphomas and leukemias. It is an important target for immunology, hematological malignancy, transplantation, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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