| Target | |
|---|---|
| Synonyms | IL4RA, IL4R, CD124, IL-4R Alpha, IL-4R-Alpha, IL4R Alpha, Interleukin-4 Receptor Subunit Alpha, Interleukin-4 Receptor Alpha Chain, IL-4 Receptor Subunit Alpha |
| Description | Recombinant Cynomolgus IL4RA protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | A0A2K5V556 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | IL4RA(Gly24-Arg232)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 25.3 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | IL4RA, also known as CD124, is a type I transmembrane glycoprotein belonging to the type I cytokine receptor family. It serves as the alpha subunit of the receptor complexes for interleukin-4 (IL-4) and interleukin-13 (IL-13). IL4RA associates with the common gamma chain to form the type I IL-4 receptor, which primarily mediates IL-4 signaling, or with IL13RA1 to form the type II receptor complex, which responds to both IL-4 and IL-13. Activation of IL4RA initiates intracellular signaling through the JAK-STAT pathway, particularly STAT6, and may also activate insulin receptor substrate proteins such as IRS1 and IRS2. IL4RA signaling regulates T helper 2 cell differentiation, immunoglobulin E production, immune-cell activation, mucus secretion, and allergic inflammation. Dysregulation of the IL-4/IL-13 signaling pathway is associated with asthma, atopic dermatitis, and other inflammatory diseases, making IL4RA an important target for immunology, inflammation, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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