| Target | |
|---|---|
| Synonyms | 5-HT1B, 5-HT1BR, Serotonin receptor 1B, 5-hydroxytryptamine receptor 1B |
| Description | Recombinant human HTR1B Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P28222 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | HTR1B(Met1-Leu46) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 31.0 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | HTR1B (5-HT1B / Serotonin receptor 1B) is a G-protein coupled receptor (GPCR) primarily expressed in the central nervous system, including the basal ganglia, cortex, and hippocampus. It couples to Gi/o proteins, inhibiting adenylyl cyclase and reducing intracellular cAMP, while modulating MAPK signaling. HTR1B regulates neurotransmitter release, mood, aggression, and vascular tone. Dysregulation is linked to migraine, depression, anxiety, and psychiatric disorders, making HTR1B a relevant therapeutic target in neuropsychiatric and vascular conditions. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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