| Target | |
|---|---|
| Synonyms | OA1, Ocular albinism type 1 protein, Xp22.3-p22.2 GPR143 |
| Description | Recombinant human GPR143 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P51810 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | GPR143(Met1-Arg27) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 29.1 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | GPR143 (G protein-coupled receptor 143 / OA1) is an intracellular G-protein coupled receptor (GPCR) primarily expressed in melanosomes of retinal pigment epithelium and melanocytes. It regulates melanosome biogenesis, pigmentation, and intracellular signaling. Mutations in GPR143 cause ocular albinism type 1 (OA1), leading to hypopigmentation, vision defects, and foveal hypoplasia. GPR143 is a key target for research into pigmentation disorders and retinal development. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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