| Target | |
|---|---|
| Synonyms | M3R, mAChR M3, ACHE2, MR3, hM3, MUSCARINIC M3 RECEPTOR |
| Description | Recombinant human CHRM3 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P20309 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | CHRM3(Met1-Gln67) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 33.2 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | CHRM3 encodes the muscarinic acetylcholine receptor M3, a G-protein coupled receptor (GPCR) that primarily couples to Gq/11 proteins, activating phospholipase C (PLC), increasing inositol triphosphate (IP₃) and diacylglycerol (DAG) levels, and mobilizing intracellular Ca²⁺. CHRM3 is widely expressed in smooth muscle, exocrine glands, pancreas, and the central nervous system, mediating smooth muscle contraction, glandular secretion, insulin release, and neuronal signaling. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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