| Target | |
|---|---|
| Synonyms | IA4; CD49D |
| Description | Recombinant human ITGA4(1-977) Acidic tail Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P13612 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | ITGA4(Met1-Thr977) Acidic tail hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 131.8 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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