ADC药物研发解决方案

抗体偶联药物( antibody-drug conjugate,ADC) 是将单克隆抗体药物的高特异性和小分子细胞毒药物的高活性相结合,用以提高肿瘤药物的靶向性、减少毒副作用。ADC抗体分子的筛选是ADC临床转化前的重要基础,是保证ADC临床有效性和安全性的关键。

缔码生物针对每个ADC热门靶点,已经开发出几十种预先开发好的先导分子,同时建立了一整套ADC临床前药效学评价平台。

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ADC开发工具

缔码生物致力于推动ADC研究,并为研究人员提供所需的工具和技术服务,以便于更好的定义精准医疗。我们邀请您加入我们的变革之旅,共创癌症治疗的未来。

平台优势

功能活性重组蛋白

1000+ 重组ECD蛋白 .

200+ 全长多穿膜蛋白

现货先导抗体分子

80+ ADC先导抗体分子 .

400+ 预制B细胞种子库

ADC 开发工具

2 评估内吞效果的IgG标记试剂

5 anti-payload 兔单抗.

成功案例

10+ 已转让ADC项目.

20+ 测试中 ADC 项目.

服务流程

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ADC 项目合作

依托强大专业的技术团队,缔码生物可为客户提供个性化的ADC开发服务,协助客户加快ADC药物研发进程。

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    案例展示

    Bioactive Proteins for ADC Drug Targets
    page-FLP100011 GPRC5D Fig.2 SDS PAGE 1
    elisa-FLP100011 GPRC5D Fig.1 Elisa 1

    QC data for human GPRC5D-Nanodisc protein (Cat. FLP100011 ): SDS-PAGE (Left) and ELISA with anti-GPRC5D mAb (Right).

    ADC Cell Killing Assay with MMAE conjugated GPRC5D Antibodies (Ab1 and Ab2)
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    Specific Cell Killing by Anti-GPRC5D Antibodies Conjugated with MMAE
    In this experiment, three cell types were tested: K562 (negative control, left), K562-GPRC5D (positive cells, center), and H929 (GPRC5D-expressing natural cell line, right). The black and red curves represent MMAE-conjugated anti-GPRC5D antibodies (Ab1/2), showing specific killing of GPRC5D-positive cells. The blue curve represents MMAE-conjugated anti-GPRC5D positive control antibodies, and the green curve represents MMAE-conjugated IgG negative control. The data demonstrates the specific cytotoxicity of anti-GPRC5D antibodies against GPRC5D-positive cells following MMAE conjugation.

    DiTag TM IgG Labeling Reagent for Antibody Internailzaiton Assay

    Antibody Internalization Assay with DiTag TM Reagents

    reagents-ame100001 internalization of labeled gprc5d antibody flow cytometry 1

    Specific Internalization of GPRC5D ADC BMK-AME100001 Conjugate in GPRC5D-Positive Cells (K562-GPRC5D Stable Expression Cell Line, Right), with No Detection in K562 Cells Lacking GPRC5D Overexpression (Left).

    reagents-AME100002 Figure1 1
    reagents-AME100002 Figure1 2

    Specific Internalization of GPRC5D ADC BMK-AME100002 Conjugate in GPRC5D-Positive Cells (K562-GPRC5D Stable Expression Cell Line, Right), with No Detection in K562 Cells Lacking GPRC5D Overexpression (Left).

    Stability Testing for DiTag TM Reagents

    reagents-ame100001 stability test 1

    Stability test of AME100001: Three storage methods are tested: lyophilization and reconstitution (black), liquid with 50% glycerol at -20℃ (red), liquid at 4℃ (blue). All three methods exhibit excellent stability.

    Reagents for ADC payload detection

    Cat. DME101003

    antibody-DME101003 MMAE Fig.1 Elisa 1

    Cat. DME101004

    antibody-DME101004 MMAE Fig.1 Elisa 1

    DME101005

    antibody-DME101005 MMAE Fig.1 Elisa 1

    DME101006

    antibody-DME101006 MMAE Fig.1 Elisa 1

    DME101007

    antibody-DME101007 MMAE Fig.1 Elisa 1

    Validation of 5 anti-MMAE rabbit monoclonal antibodies.
    ELISA plates were pre-coated with IgG-MMAE (0.2 μg/well). Serially diluted anti-MMAE monoclonal antibody solutions were added, washed, and incubated with a secondary antibody before ELISA reading. Detailed EC50 values for each antibody can be found on their respective pages.