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Human Claudin-6 full length protein -MNP

产品概述
Catalog Number FLP100004
package 50 μg ¥8000.00 ; 100 μg ¥10800.00
Description Human Claudin-6 full length membrane nanoparticles (MNPs)
Expression Host HEK293
Symbol CLDN6
ORF Size 660bp
Formulation Supplied in 1xPBS (pH 7.4)
Storage The product should be stored at -80°C. Please do not repeated freeze-thaw cycles.
ACCN NM_021195
Protein Families Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
MW The human full length Claudin-6 Protein has a MW of 23 kDa
Protein Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
UniProt ID P56747
Delivery In Stock
Images

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Figure 1. ELISA plates were pre-coated with 0.5 μg/per well purified human Claudin6 MNPs. Serial diluted Anti-Claudin6 monoclonal antibody (BME100082) solutions were added, washed, and incubated with secondary antibody before ELISA reading. From above data, the EC50 for BME100082 binding with Claudin6 MNPs is 34.36 ng/ml.

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Figure 2. FACS analysis Claudin6 membrane nanoparticle
A. Negative Control 1: Claudin6 full length membrane nanoparticles samples were stained only with Goat anti-human lgG 488 secondary antibody.
B. Negative Control 2: Control membrane nanoparticles samples were stained with anti-Claudin6 antibody (BME100082) at 2 μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
C. Negative Control 3: Claudin6 full length membrane nanoparticles samples were stained with anti-GPRC5D antibody (an irrelevant antibody) at 2 μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
D.Claudin6 full length membrane nanoparticles samples were stained with anti-Claudin6 antibody (BME100082) at 2 μg/mL, followed by Goat  anti-human IgG 488 secondary antibody.

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