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Human CLDN18.2 full length protein-synthetic nanodisc

产品概述
Catalog Number FLP100014
package 10 μg ¥6300.00 ;50 μg ¥30000.00 ; 100 μg ¥55000.00
Description Human CLDN18.2 full length protein-synthetic nanodisc
Expression Host HEK293
Symbol CLDN18.2
ORF Size 783bp
Formulation Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)
Storage The product should be stored at -80°C. Please do not repeated freeze-thaw cycles.
ACCN NM_001775
Protein Families Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
MW The human full length CLDN18.2 Protein has a MW of 27.5 kDa
Protein Summary The protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
UniProt ID P56856
Delivery In Stock
Images

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Figure 1. Elisa plates were added with Flag Tag CLDN18.2-Nanodisc (0.2μg/per well) on an anti-Flag monoclonal antibody pre-coated (0.2μg/per well) plate. Serial diluted anti- CLDN18.2 monoclonal antibody (BME100075) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti- CLDN18.2 monoclonal antibody binding with CLDN18.2-Nanodisc is 593.6ng/ml.

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Figure 2. Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

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Figure3. Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

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