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Human CLDN18.2 full length protein-VLP

Catalog Number FLP100006
package 50 μg ¥8000.00 ; 100 μg ¥10800.00
Description Human Full length CLDN18.2 Protein-VLP
Expression Host HEK293
Symbol CLDN18.2
ORF Size 783bp
Formulation Supplied in 1xPBS (pH 7.4)and 15% Trehalose
Storage The product should be stored at -80°C. Please do not repeated freeze-thaw cycles.
ACCN NM_001775
Protein Families Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
MW The Human CLDN18.2 Protein has a predicted MW of 29 kDa.Due to PTM, the actual MW on SDS-PAGE gel is around 50kDa.
Protein Summary The protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
UniProt ID P56856
Delivery In Stock

Figure1. ELISA plates were pre-coated with 0.5ug/per well purified human CLDN18.2 VLP. Serial diluted Anti-CLDN18.2 monoclonal antibody (Zolbetuximab biosililar; IMAB362) solutions were added, washed, and incubated with secondary antibody before ELISA reading. From above data, the EC50 for IMAB362 binding with CLDN18.2 VLP is 15.37ng/ml. 

Figure2. FACS analysis of CLDN18.2 VLP
A. Negative Control 1: CLDN18.2 VLP were stained only with Goat anti-human IgG Fc-PE secondary antibody.
B. Negative Control 2: Control VLP were stained with anti-CLDN18.2 antibody (Zolbetuximab biosimilar; IMAB362) at 1μg/mL, followed by Goat anti-human IgG Fc-PE secondary antibody. 
C. Negative Control 3: CLDN18.2 VLP were stained with anti-BCMA antibody(an irrelevant antibody)at 1μg/mL, followed by Goat anti-human IgG Fc-PE secondary antibody. 
D. CLDN18.2 VLP were stained with anti-CLDN18.2 antibody(Zolbetuximab biosimilar; IMAB362)at 1μg/mL, followed by Goat anti-human IgG Fc-PE secondary antibody.

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