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Human CLDN18.2 full length protein-VLP
| Catalog Number | FLP100006 |
|---|---|
| package | 50 μg ￥8000.00 ; 100 μg ￥10800.00 |
| Description | Human Full length CLDN18.2 Protein-VLP |
| Expression Host | HEK293 |
| Symbol | CLDN18.2 |
| ORF Size | 783bp |
| Formulation | Supplied in 1xPBS (pH 7.4）and 15% Trehalose |
| Storage | The product should be stored at -80°C. Please do not repeated freeze-thaw cycles. |
| ACCN | NM_001775 |
| Protein Families | Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction |
| MW | The Human CLDN18.2 Protein has a predicted MW of 29 kDa.Due to PTM, the actual MW on SDS-PAGE gel is around 50kDa. |
| Protein Summary | The protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010] |
| UniProt ID | P56856 |
| Delivery | In Stock |
| Images |
Figure1. ELISA plates were pre-coated with 0.5ug/per well purified human CLDN18.2 VLP. Serial diluted Anti-CLDN18.2 monoclonal antibody (Zolbetuximab biosililar; IMAB362) solutions were added, washed, and incubated with secondary antibody before ELISA reading. From above data, the EC50 for IMAB362 binding with CLDN18.2 VLP is 15.37ng/ml.
Figure2. FACS analysis of CLDN18.2 VLP |
| 说明书 | 立即下载 | COA | 立即下载 |
|---|---|---|---|
| MSDS | 立即下载 | ||
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