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Human TNFSF12 Protein, hFc Tag

产品概述
Catalog Number PME100105
Package 10 μg ¥600.00 ; 50 μg ¥2400.00 ; 100 μg ¥3600.00
Description Recombinant Human TNFSF12 Protein with N-terminal Human Fc tag
Synonyms APO3L, DR3LG, TNLG4A, TWEAK
Delivery In Stock
Uniprot ID O43508
Expression Host HEK293
Tag N-Human Fc tag
Molecular Characterization 这里上传图片
Molecular Weight The protein has a predicted molecular mass of 43.3 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).
Usage Research use only
Images

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Figure 1. Human TNFSF12 Protein, hFc Tag on SDS-PAGE under reducing condition.

Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
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